BLM prevents instability of structure-forming DNA sequences at common fragile sites

Genome instability often arises at common fragile sites (CFSs) leading to cancer-associated chromosomal rearrangements. However, the underlying mechanisms of how CFS protection is achieved is not well understood. We demonstrate that BLM plays an important role in the maintenance of genome stability...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Hailong, Li, Shibo, Zhang, Huimin, Wang, Ya, Hao, Shuailin, Wu, Xiaohua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6289451/
https://www.ncbi.nlm.nih.gov/pubmed/30496191
http://dx.doi.org/10.1371/journal.pgen.1007816

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6289451/
https://www.ncbi.nlm.nih.gov/pubmed/30496191
http://dx.doi.org/10.1371/journal.pgen.1007816

Ejemplares similares