Cargando…
Coevolving residues inform protein dynamics profiles and disease susceptibility of nSNVs
The conformational dynamics of proteins is rarely used in methodologies used to predict the impact of genetic mutations due to the paucity of three-dimensional protein structures as compared to the vast number of available sequences. Until now a three-dimensional (3D) structure has been required to...
| Autores principales: | , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2018
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6289467/ https://www.ncbi.nlm.nih.gov/pubmed/30496278 http://dx.doi.org/10.1371/journal.pcbi.1006626 |