SIRT2 knockout exacerbates insulin resistance in high fat-fed mice

The NAD(+)-dependent deacetylase SIRT2 is unique amongst sirtuins as it is effective in the cytosol, as well as the mitochondria. Defining the role of cytosolic acetylation state in specific tissues is difficult since even physiological effects at the whole body level are unknown. We hypothesized th...

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Detalles Bibliográficos
Autores principales: Lantier, Louise, Williams, Ashley S., Hughey, Curtis C., Bracy, Deanna P., James, Freyja D., Ansari, Muhammad A., Gius, David, Wasserman, David H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6289500/
https://www.ncbi.nlm.nih.gov/pubmed/30533032
http://dx.doi.org/10.1371/journal.pone.0208634

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6289500/
https://www.ncbi.nlm.nih.gov/pubmed/30533032
http://dx.doi.org/10.1371/journal.pone.0208634

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