Cargando…

Design Optimization of Tumor Vasculature-Bound Nanoparticles

Nanotherapy may constitute a promising approach to target tumors with anticancer drugs while minimizing systemic toxicity. Computational modeling can enable rapid evaluation of nanoparticle (NP) designs and numerical optimization. Here, an optimization study was performed using an existing tumor mod...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chamseddine, Ibrahim M., Frieboes, Hermann B., Kokkolaras, Michael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290012/ https://www.ncbi.nlm.nih.gov/pubmed/30538267 http://dx.doi.org/10.1038/s41598-018-35675-y

Ejemplares similares

Multi-objective optimization of tumor response to drug release from vasculature-bound nanoparticles
por: Chamseddine, Ibrahim M., et al.
Publicado: (2020)

Computational Modeling of Tumor Response to Drug Release from Vasculature-Bound Nanoparticles
por: Curtis, Louis T., et al.
Publicado: (2015)

A Computational Model for Predicting Nanoparticle Accumulation in Tumor Vasculature
por: Frieboes, Hermann B., et al.
Publicado: (2013)

Weekly Nowcasting of New COVID-19 Cases Using Past Viral Load Measurements
por: Khalil, Athar, et al.
Publicado: (2022)

Macrophage Polarization Contributes to the Anti-Tumoral Efficacy of Mesoporous Nanovectors Loaded with Albumin-Bound Paclitaxel
por: Leonard, Fransisca, et al.
Publicado: (2017)

Distribution of PLGA-modified nanoparticles in 3D cell culture models of hypo-vascularized tumor tissue
por: Sims, Lee B., et al.
Publicado: (2017)

Tumor Vasculature Targeted Photodynamic Therapy for Enhanced Delivery of Nanoparticles
por: Zhen, Zipeng, et al.
Publicado: (2014)

Multicompartment modeling of protein shedding kinetics during vascularized tumor growth
por: Machiraju, Gautam B., et al.
Publicado: (2020)

Enhanced uptake and transport of PLGA-modified nanoparticles in cervical cancer
por: Sims, Lee B., et al.
Publicado: (2016)

Modeling of Nanotherapy Response as a Function of the Tumor Microenvironment: Focus on Liver Metastasis
por: Frieboes, Hermann B., et al.
Publicado: (2020)

Nanoparticle-mediated drug delivery to treat infections in the female reproductive tract: evaluation of experimental systems and the potential for mathematical modeling
por: Sims, Lee B, et al.
Publicado: (2018)

Mathematical modeling of tumor-associated macrophage interactions with the cancer microenvironment
por: Mahlbacher, Grace, et al.
Publicado: (2018)

“Designer cytokines” targeting the tumor vasculature—think global and act local
por: Kammertoens, Thomas, et al.
Publicado: (2020)

Neuropilins in the Context of Tumor Vasculature
por: Niland, Stephan, et al.
Publicado: (2019)

L1 in tumor vasculature
por: Cavallaro, Ugo
Publicado: (2016)

Normalizing Tumor Vasculature to Reduce Hypoxia, Enhance Perfusion, and Optimize Therapy Uptake
por: Matuszewska, Kathy, et al.
Publicado: (2021)

Targeted disruption of tumor vasculature via polyphenol nanoparticles to improve brain cancer treatment
por: Liu, Fuyao, et al.
Publicado: (2022)

Tumor vasculature is a key determinant for the efficiency of nanoparticle-mediated siRNA delivery
por: Li, L, et al.
Publicado: (2012)

Nucleic Acid Sensing in the Tumor Vasculature
por: Baris, Adrian M., et al.
Publicado: (2021)

Gold nanoparticles attenuate metastasis by tumor vasculature normalization and epithelial–mesenchymal transition inhibition
por: Li, Wei, et al.
Publicado: (2017)

Optimization of Pulmonary Vasculature Tridimensional Phenotyping in The Rat Fetus
por: Aydin, Emrah, et al.
Publicado: (2019)

Detection of Phosphatidylcholine-Coated Gold Nanoparticles in Orthotopic Pancreatic Adenocarcinoma using Hyperspectral Imaging
por: England, Christopher G., et al.
Publicado: (2015)

Vasculature Disruption Enhances Bacterial Targeting of Autochthonous Tumors
por: Drees, Jeremy J., et al.
Publicado: (2015)

Simulation of the Protein-Shedding Kinetics of a Fully Vascularized Tumor
por: Frieboes, Hermann B., et al.
Publicado: (2015)

Normalization of tumor vasculature by R-Ras
por: Sawada, Junko, et al.
Publicado: (2012)

Optimization of the dorsal skinfold window chamber model and multi-parametric characterization of tumor-associated vasculature
por: Maeda, Azusa, et al.
Publicado: (2014)

Defining the role of the tumor vasculature in antitumor immunity and immunotherapy
por: Schaaf, Marco B., et al.
Publicado: (2018)

Thioaptamer Conjugated Liposomes for Tumor Vasculature Targeting
por: Mann, Aman P., et al.
Publicado: (2010)

Targeting the tumor vasculature to enhance T cell activity
por: Lanitis, Evripidis, et al.
Publicado: (2015)

A review of the development of tumor vasculature and its effects on the tumor microenvironment
por: Forster, Jake C, et al.
Publicado: (2017)

Predicting drug pharmacokinetics and effect in vascularized tumors using computer simulation
por: Sinek, John P., et al.
Publicado: (2008)

The tumor vasculature an attractive CAR T cell target in solid tumors
por: Akbari, Parvin, et al.
Publicado: (2019)

Control of the Adaptive Immune Response by Tumor Vasculature
por: Mauge, Laetitia, et al.
Publicado: (2014)

Normalization of Tumor Vasculature by Oxygen Microbubbles with Ultrasound
por: Ho, Yi-Ju, et al.
Publicado: (2019)

Immunotherapies targeting tumor vasculature: challenges and opportunities
por: Dianat-Moghadam, Hassan, et al.
Publicado: (2023)

Targeting Tissue Factor to Tumor Vasculature to Induce Tumor Infarction
por: Berdel, Andrew F., et al.
Publicado: (2021)

Hybrid modeling frameworks of tumor development and treatment
por: Chamseddine, Ibrahim M., et al.
Publicado: (2019)

Simulation of Multispecies Desmoplastic Cancer Growth via a Fully Adaptive Non-linear Full Multigrid Algorithm
por: Ng, Chin F., et al.
Publicado: (2018)

Targeting the tumor vasculature with engineered cystine-knot miniproteins
por: Lui, Bonny Gaby, et al.
Publicado: (2020)

Endothelial YAP/TAZ Signaling in Angiogenesis and Tumor Vasculature
por: Hooglugt, Aukie, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_nirbifljoiae6lsnid1lbshvqf