Ultrahigh specificity in a network of computationally designed protein-interaction pairs

Protein networks in all organisms comprise homologous interacting pairs. In these networks, some proteins are specific, interacting with one or a few binding partners, whereas others are multispecific and bind a range of targets. We describe an algorithm that starts from an interacting pair and desi...

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Detalles Bibliográficos
Autores principales: Netzer, Ravit, Listov, Dina, Lipsh, Rosalie, Dym, Orly, Albeck, Shira, Knop, Orli, Kleanthous, Colin, Fleishman, Sarel J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290019/
https://www.ncbi.nlm.nih.gov/pubmed/30538236
http://dx.doi.org/10.1038/s41467-018-07722-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290019/
https://www.ncbi.nlm.nih.gov/pubmed/30538236
http://dx.doi.org/10.1038/s41467-018-07722-9

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