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Ultrahigh specificity in a network of computationally designed protein-interaction pairs
Protein networks in all organisms comprise homologous interacting pairs. In these networks, some proteins are specific, interacting with one or a few binding partners, whereas others are multispecific and bind a range of targets. We describe an algorithm that starts from an interacting pair and desi...
Autores principales: | Netzer, Ravit, Listov, Dina, Lipsh, Rosalie, Dym, Orly, Albeck, Shira, Knop, Orli, Kleanthous, Colin, Fleishman, Sarel J. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290019/ https://www.ncbi.nlm.nih.gov/pubmed/30538236 http://dx.doi.org/10.1038/s41467-018-07722-9 |
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