Tropinone synthesis via an atypical polyketide synthase and P450-mediated cyclization

Tropinone is the first intermediate in the biosynthesis of the pharmacologically important tropane alkaloids that possesses the 8-azabicyclo[3.2.1]octane core bicyclic structure that defines this alkaloid class. Chemical synthesis of tropinone was achieved in 1901 but the mechanism of tropinone bios...

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Detalles Bibliográficos
Autores principales: Bedewitz, Matthew A., Jones, A. Daniel, D’Auria, John C., Barry, Cornelius S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290073/
https://www.ncbi.nlm.nih.gov/pubmed/30538251
http://dx.doi.org/10.1038/s41467-018-07671-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290073/
https://www.ncbi.nlm.nih.gov/pubmed/30538251
http://dx.doi.org/10.1038/s41467-018-07671-3

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