N-terminal Huntingtin (Htt) phosphorylation is a molecular switch regulating Htt aggregation, helical conformation, internalization, and nuclear targeting

Huntington's disease is a fatal neurodegenerative disorder resulting from a CAG repeat expansion in the first exon of the gene encoding the Huntingtin protein (Htt). Phosphorylation of this protein region (Httex1) has been shown to play important roles in regulating the structure, toxicity, and...

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Detalles Bibliográficos
Autores principales: DeGuire, Sean M., Ruggeri, Francesco S., Fares, Mohamed-Bilal, Chiki, Anass, Cendrowska, Urszula, Dietler, Giovanni, Lashuel, Hilal A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2018
Materias:
Molecular Bases of Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290154/
https://www.ncbi.nlm.nih.gov/pubmed/30185623
http://dx.doi.org/10.1074/jbc.RA118.004621

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290154/
https://www.ncbi.nlm.nih.gov/pubmed/30185623
http://dx.doi.org/10.1074/jbc.RA118.004621

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