Cargando…

Pathogenesis of Acquired Aplastic Anemia and the Role of the Bone Marrow Microenvironment

Aplastic anemia (AA) is characterized by bone marrow (BM) hypocellularity, resulting in peripheral cytopenias. An antigen-driven and likely auto-immune dysregulated T-cell homeostasis results in hematopoietic stem cell injury, which ultimately leads to the pathogenesis of the acquired form of this d...

Descripción completa

Detalles Bibliográficos
Autores principales:	Medinger, Michael, Drexler, Beatrice, Lengerke, Claudia, Passweg, Jakob
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290278/ https://www.ncbi.nlm.nih.gov/pubmed/30568919 http://dx.doi.org/10.3389/fonc.2018.00587

Ejemplares similares

The role of androgen therapy in acquired aplastic anemia and other bone marrow failure syndromes
por: Nassani, Momen, et al.
Publicado: (2023)

Current evidence and the emerging role of eltrombopag in severe aplastic anemia
por: Drexler, Beatrice, et al.
Publicado: (2021)

Stress and catecholamines modulate the bone marrow microenvironment to promote tumorigenesis
por: Hanns, Pauline, et al.
Publicado: (2019)

Novel therapeutic options in Acute Myeloid Leukemia
por: Medinger, Michael, et al.
Publicado: (2016)

Very long-term follow-up of aplastic anemia treated with immunosuppressive therapy or allogeneic hematopoietic cell transplantation
por: Drexler, Beatrice, et al.
Publicado: (2020)

Gut inflammation in the pathogenesis of acquired aplastic anemia
por: Zhao, Xi-Chen, et al.
Publicado: (2020)

Mesenchymal Stem Cell Benefits Observed in Bone Marrow Failure and Acquired Aplastic Anemia
por: Gonzaga, Vivian Fonseca, et al.
Publicado: (2017)

Dioscin Regulating Bone Marrow Apoptosis in Aplastic Anemia
por: Zhang, Le, et al.
Publicado: (2022)

Exosomes in the Pathogenesis and Treatment of Multiple Myeloma in the Context of the Bone Marrow Microenvironment
por: Chen, Tianzeng, et al.
Publicado: (2020)

Hypoplastic myelodysplastic syndrome and acquired aplastic anemia: Immune-mediated bone marrow failure syndromes (Review)
por: Votavova, Hana, et al.
Publicado: (2021)

A Deep Learning Model for the Automatic Recognition of Aplastic Anemia, Myelodysplastic Syndromes, and Acute Myeloid Leukemia Based on Bone Marrow Smear
por: Wang, Meifang, et al.
Publicado: (2022)

NOTCH signaling in immune-mediated bone marrow failure of aplastic anemia
por: Minter, Lisa M
Publicado: (2013)

Enhanced Adipogenicity of Bone Marrow Mesenchymal Stem Cells in Aplastic Anemia
por: Tripathy, Naresh Kumar, et al.
Publicado: (2014)

Bone Marrow Plasma Cytokine Signature Profiles in Severe Aplastic Anemia
por: Liu, Bingnan, et al.
Publicado: (2020)

Single-Cell RNA-Seq of Bone Marrow Cells in Aplastic Anemia
por: Tonglin, Hu, et al.
Publicado: (2022)

Magnetic resonance imaging of the bone marrow after bone marrow transplantation or immunosuppressive therapy in aplastic anemia.
por: Park, J. M., et al.
Publicado: (2001)

Immunosuppressive Treatment in Children with Acquired Aplastic Anemia
por: Yıldırmak, Yıldız, et al.
Publicado: (2012)

Genetic Associations in Acquired Immune-Mediated Bone Marrow Failure Syndromes: Insights in Aplastic Anemia and Chronic Idiopathic Neutropenia
por: Mavroudi, Irene, et al.
Publicado: (2012)

CD106 is a novel mediator of bone marrow mesenchymal stem cells via NF-κB in the bone marrow failure of acquired aplastic anemia
por: Lu, Shihong, et al.
Publicado: (2017)

Mitochondrial DNA Aberrations of Bone Marrow Cells from Patients with Aplastic Anemia
por: Kim, Hye-Ran, et al.
Publicado: (2008)

Hypercellular bone marrow in aplastic anemia: A case report of two patients
por: Sweeney, Ryan, et al.
Publicado: (2021)

Cancers after HLA-matched related Bone Marrow Transplantation for Aplastic Anemia
por: Vo, Phuong, et al.
Publicado: (2021)

Development of a patient-reported outcome questionnaire for aplastic anemia and paroxysmal nocturnal hemoglobinuria (PRO-AA/PNH)
por: Weisshaar, Kimmo, et al.
Publicado: (2020)

Hematopoietic Stem Cell Regulation by Type I and II Interferons in the Pathogenesis of Acquired Aplastic Anemia
por: Smith, Julianne N. P., et al.
Publicado: (2016)

PB2479: ELTROMBOPAG, BUT NOT AVATROMBOPAG, REGULATES BONE MARROW MICROENVIRONMENT MIMICKING APLASTIC ANEMIA THROUGH DOWN-REGULATION OF FERROPTOSIS INHIBITOR
por: Ji, Jiang, et al.
Publicado: (2023)

Effect of antithymocyte globulin source on outcomes of bone marrow transplantation for severe aplastic anemia
por: Kekre, Natasha, et al.
Publicado: (2017)

THPO gene variants in patients with acquired aplastic anemia
por: Padilha, Pedro Henrique, et al.
Publicado: (2018)

Editorial: The role of the bone marrow microenvironment in multiple myeloma evolution and therapy
por: Schinke, Carolina, et al.
Publicado: (2023)

Aplastic Anemia as a Roadmap for Bone Marrow Failure: An Overview and a Clinical Workflow
por: Solimando, Antonio G., et al.
Publicado: (2022)

P1335: REPAIR OF DYSFUNCTIONAL BONE MARROW ENDOTHELIAL CELLS ALLEVIATES APLASTIC ANEMIA
por: Tang, Shu-Qian, et al.
Publicado: (2023)

Feasibility of electronic patient-reported outcome monitoring and self-management program in aplastic anemia and paroxysmal nocturnal hemoglobinuria—a pilot study (ePRO-AA-PNH)
por: Bänziger, Silas, et al.
Publicado: (2022)

Monocytic myeloid-derived suppressive cells mitigate over-adipogenesis of bone marrow microenvironment in aplastic anemia by inhibiting CD8(+) T cells
por: Qu, Ying, et al.
Publicado: (2022)

Regulation of Malignant Hematopoiesis by Bone Marrow Microenvironment
por: Asada, Noboru
Publicado: (2018)

Bone Marrow Senescence and the Microenvironment of Hematological Malignancies
por: Hellmich, Charlotte, et al.
Publicado: (2020)

Impaired immunosuppressive role of myeloid-derived suppressor cells in acquired aplastic anemia
por: Dong, Peiyuan, et al.
Publicado: (2022)

Single-cell RNA sequencing depicts metabolic changes in children with aplastic anemia
por: Zhou, Qin, et al.
Publicado: (2023)

Efficacy of eltrombopag with immunosuppressive therapy for children with acquired aplastic anemia
por: Zhao, Yufei, et al.
Publicado: (2023)

Angiogenesis in myeloproliferative neoplasms, new markers and future directions
por: Medinger, Michael, et al.
Publicado: (2014)

Human Acquired Aplastic Anemia Patients' Bone-Marrow-Derived Mesenchymal Stem Cells Are Not Influenced by Hematopoietic Compartment and Maintain Stemness and Immune Properties
por: Sharma, Vandana, et al.
Publicado: (2021)

Expression Level of IL-6 Secreted by Bone Marrow Stromal Cells in Mice with Aplastic Anemia
por: Chen, Yong Feng, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_rfogvvn28jo7823p3fruicbgvm