Transport-exclusion pharmacology to localize lactate dehydrogenase activity within cells

BACKGROUND: Recent in vitro and in vivo work has shown that lactate provides an important source of carbon for metabolic reactions in cancer cell mitochondria. An interesting question is whether lactate is oxidized by lactate dehydrogenase (LDH) in the cytosol and/or in mitochondria. Since metabolic...

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Detalles Bibliográficos
Autores principales: Niu, Xiangfeng, Chen, Ying-Jr, Crawford, Peter A., Patti, Gary J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290536/
https://www.ncbi.nlm.nih.gov/pubmed/30559963
http://dx.doi.org/10.1186/s40170-018-0192-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290536/
https://www.ncbi.nlm.nih.gov/pubmed/30559963
http://dx.doi.org/10.1186/s40170-018-0192-5

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