Cargando…

Transport-exclusion pharmacology to localize lactate dehydrogenase activity within cells

BACKGROUND: Recent in vitro and in vivo work has shown that lactate provides an important source of carbon for metabolic reactions in cancer cell mitochondria. An interesting question is whether lactate is oxidized by lactate dehydrogenase (LDH) in the cytosol and/or in mitochondria. Since metabolic...

Descripción completa

Detalles Bibliográficos
Autores principales:	Niu, Xiangfeng, Chen, Ying-Jr, Crawford, Peter A., Patti, Gary J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Rapid Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290536/ https://www.ncbi.nlm.nih.gov/pubmed/30559963 http://dx.doi.org/10.1186/s40170-018-0192-5

Ejemplares similares

Regulation of Dihydropyrimidine Dehydrogenase and Pyrimidine Nucleoside Phosphorylase Activities by Growth Factors and Subsequent Effects on 5‐Fluorouracil Sensitivity in Tumor Cells
por: Ueda, Masatsugu, et al.
Publicado: (2000)

Dehydrozaluzanin C, a novel type of anti-bacterial agent which targets transporting proteins, Opp and OpuC
por: Qin, Xiangyang, et al.
Publicado: (2021)

Selective Pharmacological Augmentation of Hippocampal Activity Produces a Sustained Antidepressant-Like Response without Abuse-Related or Psychotomimetic Effects
por: Carreno, Flavia R., et al.
Publicado: (2017)

Exploring the anti-cancer effects of Panax notoginseng through network pharmacology and molecular modeling
por: Thorpe, Erin M., et al.
Publicado: (2023)

Lactate Dehydrogenase: The Beacon of Hope?
por: Pandarathodiyil, Anitha Krishnan, et al.
Publicado: (2022)

Structure of a filamentous virus uncovers familial ties within the archaeal virosphere
por: Wang, Fengbin, et al.
Publicado: (2020)

Fine structural localization of potassium-stimulated rho nitrophenylphosphatase activity in denrites of the cerebral cortex
por: Broderson, S. H., et al.
Publicado: (1978)

Pharmacologically relevant doses of valproate upregulate CD20 expression in three diffuse large B-cell lymphoma patients in vivo
por: Damm, Jesper Kofoed, et al.
Publicado: (2015)

Understanding the Broader Impacts Of Alcohol Marketing: Time For a Research Agenda Which Includes Adults
por: Critchlow, Nathan, et al.
Publicado: (2021)

Local conduction during acute myocardial infarction in rats: Interplay between central sympathetic activation and endothelin
por: Kolettis, Theofilos M., et al.
Publicado: (2017)

Impaired riboflavin transport due to missense mutations in SLC52A2 causes Brown-Vialetto-Van Laere syndrome
por: Haack, Tobias B., et al.
Publicado: (2012)

Ultra-conserved non-coding sequences within the FOXF1 enhancer are critical for human lung development
por: Szafranski, Przemyslaw, et al.
Publicado: (2022)

Alternative approach for management of an electrical storm in Brugada syndrome:Importance of primary ablation within a narrow time window
por: Talib, Ahmed Karim, et al.
Publicado: (2016)

Identification of African swine fever virus genomic DNAs in wild boar habitats within outbreak regions in South Korea
por: Lee, Kyung-Lak, et al.
Publicado: (2021)

COVID-19 vaccine: Call for employees in international transportation industries and international travelers as the first priority in global distribution
por: Yu, Zhuo, et al.
Publicado: (2021)

Complete chloroplast genome of a rare and endangered plant species Phalaenopsis zhejiangensis: genomic features and phylogenetic relationship within Orchidaceae
por: Jiang, Ming, et al.
Publicado: (2021)

A Simple Derivation of the Distribution of Pairwise Local Protein Sequence Alignment Scores
por: Bastien, Olivier
Publicado: (2008)

Aquaporin 4-Specific T Cells in Neuromyelitis Optica Exhibit a Th17 Bias and Recognize Clostridium ABC Transporter
por: Varrin-Doyer, Michel, et al.
Publicado: (2012)

Enhanced national surveillance of severe acute respiratory infections (SARI) within COVID-19 surveillance, Slovenia, weeks 13 to 37 2021
por: Klavs, Irena, et al.
Publicado: (2021)

Early transconjunctival needling revision with 5-fluorouracil versus medical treatment in encapsulated blebs: a 12-month prospective study
por: Suzuki, Ricardo, et al.
Publicado: (2013)

Enhanced Tumor Localization of Monoclonal Antibody by Treatment with Kininase II Inhibitor and Angiotensin II
por: Noguchi, Akinori, et al.
Publicado: (1992)

Cattell-Braasch maneuver combined with local hypothermia during superior mesenteric artery resection in pancreatectomy
por: Westermark, Sofia, et al.
Publicado: (2016)

Immunohistochemical Localization of Hepatocyte Growth Factor Protein in Pancreas Islet A‐Cells of Man and Rats
por: Tsuda, Hiroyuki, et al.
Publicado: (1992)

Nuclear Localization of Immunoreactive β‐Catenin Is Specific to Familial Adenomatous Polyposis in Papillary Thyroid Carcinoma
por: Kurihara, Katsumi, et al.
Publicado: (2000)

Characterisation of vaccine breakthrough infections of SARS-CoV-2 Delta and Alpha variants and within-host viral load dynamics in the community, France, June to July 2021
por: Blanquart, François, et al.
Publicado: (2021)

Specialized Localization of P‐Glycoprotein Recognized by MRK 16 Monoclonal Antibody in Endothelial Cells of the Brain and the Spinal Cord
por: Sugawara, Isamu, et al.
Publicado: (1990)

LncRNA MIR205HG expression predicts efficacy of neoadjuvant chemotherapy for patients with locally advanced breast cancer
por: Xu, Yaqian, et al.
Publicado: (2021)

A common missense variant of monocarboxylate transporter 9 (MCT9/SLC16A9) gene is associated with renal overload gout, but not with all gout susceptibility
por: Nakayama, Akiyoshi, et al.
Publicado: (2013)

Severe acute hepatitis and acute liver failure of unknown origin in children: a questionnaire-based study within 34 paediatric liver centres in 22 European countries and Israel, April 2022
por: de Kleine, Ruben H, et al.
Publicado: (2022)

Brown-Vialetto-Van Laere and Fazio Londe syndrome is associated with a riboflavin transporter defect mimicking mild MADD: a new inborn error of metabolism with potential treatment
por: Bosch, Annet M., et al.
Publicado: (2010)

Use of a Local Immunotherapy as an Adjunctive Tool for the Generation of Human Monoclonal Antibodies from Regional Lymph Nodes of Colonic Cancer Patients
por: Yagyu, Toshio, et al.
Publicado: (1992)

Within-patient horizontal transfer of pOXA-48 from a hypervirulent Klebsiella pneumoniae SL218 to Serratia marcescens following spread of the K. pneumoniae isolate among hospitalised patients, Denmark, 2021
por: Nielsen, Karen Leth, et al.
Publicado: (2023)

Long-Term Use of Maintenance Systemic Corticosteroids is Associated with Multiple Adverse Conditions in a Large, Real-World Cohort of US Adults with Severe Asthma
por: Lugogo, Njira, et al.
Publicado: (2022)

Intravenous Immunoglobulin G (IVIG) Need Assessment Survey Toward Local Manufacturing of IVIG Using a Mini-Pool Plasma Fractionation Technique
por: Bekele, Bisrat, et al.
Publicado: (2023)

Local Salmonella Enteritidis restaurant outbreak investigation in England provides further evidence for eggs as source in widespread international cluster, March to April 2023
por: Benson, Helen E, et al.
Publicado: (2023)

Lactate dehydrogenase supports lactate oxidation in mitochondria isolated from different mouse tissues
por: Young, Adrian, et al.
Publicado: (2019)

Effects of metoclopramide on the mouse anterior pituitary during the estrous cycle
por: Gomes, Regina Célia Teixeira, et al.
Publicado: (2011)

Precise Localization of the Excision Repair Gene, ERCC5, to Human Chromosome 13q32.3‐q33.1 by Direct R‐Banding Fluorescence in situ Hybridization
por: Takahashi, Ei‐ichi, et al.
Publicado: (1992)

Comparing Paclitaxel Plus Fluorouracil Versus Cisplatin Plus Fluorouracil in Chemoradiotherapy for Locally Advanced Esophageal Squamous Cell Cancer: A Randomized, Multicenter, Phase III Clinical Trial
por: Chen, Yun, et al.
Publicado: (2019)

Lactate Metabolism is Associated with Mammalian Mitochondria
por: Chen, Ying-Jr, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_oce9l5v4jrmqf29o2vp6aahjle