Modulation of the Microenvironment Surrounding the Active Site of Penicillin G Acylase Immobilized on Acrylic Carriers Improves the Enzymatic Synthesis of Cephalosporins

The catalytic properties of penicillin G acylase (PGA) from Escherichia coli in kinetically controlled synthesis of β-lactam antibiotics are negatively affected upon immobilization on hydrophobic acrylic carriers. Two strategies have been here pursued to improve the synthetic performance of PGA immo...

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Detalles Bibliográficos
Autores principales: Bonomi, Paolo, Bavaro, Teodora, Serra, Immacolata, Tagliani, Auro, Terreni, Marco, Ubiali, Daniela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290566/
https://www.ncbi.nlm.nih.gov/pubmed/24264137
http://dx.doi.org/10.3390/molecules181114349

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290566/
https://www.ncbi.nlm.nih.gov/pubmed/24264137
http://dx.doi.org/10.3390/molecules181114349

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