Bio-Activity and Dereplication-Based Discovery of Ophiobolins and Other Fungal Secondary Metabolites Targeting Leukemia Cells

The purpose of this study was to identify and characterize fungal natural products (NPs) with in vitro bioactivity towards leukemia cells. We based our screening on a combined analytical and bio-guided approach of LC-DAD-HRMS dereplication, explorative solid-phase extraction (E-SPE), and a co-cultur...

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Detalles Bibliográficos
Autores principales: Bladt, Tanja Thorskov, Dürr, Claudia, Knudsen, Peter Boldsen, Kildgaard, Sara, Frisvad, Jens Christian, Gotfredsen, Charlotte Held, Seiffert, Martina, Larsen, Thomas Ostenfeld
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290568/
https://www.ncbi.nlm.nih.gov/pubmed/24287995
http://dx.doi.org/10.3390/molecules181214629

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290568/
https://www.ncbi.nlm.nih.gov/pubmed/24287995
http://dx.doi.org/10.3390/molecules181214629

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