Large-Scale Solvent-Free Chlorination of Hydroxy-Pyrimidines, -Pyridines, -Pyrazines and -Amides Using Equimolar POCl(3)

Chlorination with equimolar POCl(3) can be efficiently achieved not only for hydroxypyrimidines, but also for many other substrates such as 2-hydroxy-pyridines, -quinoxalines, or even -amides. The procedure is solvent-free and involves heating in a sealed reactor at high temperatures using one equiv...

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Detalles Bibliográficos
Autores principales: Wang, Han, Wen, Kun, Wang, Le, Xiang, Ye, Xu, Xiaocheng, Shen, Yongjia, Sun, Zhihua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290571/
https://www.ncbi.nlm.nih.gov/pubmed/22508333
http://dx.doi.org/10.3390/molecules17044533

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290571/
https://www.ncbi.nlm.nih.gov/pubmed/22508333
http://dx.doi.org/10.3390/molecules17044533

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