Large-Scale Solvent-Free Chlorination of Hydroxy-Pyrimidines, -Pyridines, -Pyrazines and -Amides Using Equimolar POCl(3)

Chlorination with equimolar POCl(3) can be efficiently achieved not only for hydroxypyrimidines, but also for many other substrates such as 2-hydroxy-pyridines, -quinoxalines, or even -amides. The procedure is solvent-free and involves heating in a sealed reactor at high temperatures using one equiv...

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Autores principales: Wang, Han, Wen, Kun, Wang, Le, Xiang, Ye, Xu, Xiaocheng, Shen, Yongjia, Sun, Zhihua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290571/
https://www.ncbi.nlm.nih.gov/pubmed/22508333
http://dx.doi.org/10.3390/molecules17044533
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author Wang, Han
Wen, Kun
Wang, Le
Xiang, Ye
Xu, Xiaocheng
Shen, Yongjia
Sun, Zhihua
author_facet Wang, Han
Wen, Kun
Wang, Le
Xiang, Ye
Xu, Xiaocheng
Shen, Yongjia
Sun, Zhihua
author_sort Wang, Han
collection PubMed
description Chlorination with equimolar POCl(3) can be efficiently achieved not only for hydroxypyrimidines, but also for many other substrates such as 2-hydroxy-pyridines, -quinoxalines, or even -amides. The procedure is solvent-free and involves heating in a sealed reactor at high temperatures using one equivalent of pyridine as base. It is suitable for large scale (multigram) batch preparations.
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spelling pubmed-62905712018-12-13 Large-Scale Solvent-Free Chlorination of Hydroxy-Pyrimidines, -Pyridines, -Pyrazines and -Amides Using Equimolar POCl(3) Wang, Han Wen, Kun Wang, Le Xiang, Ye Xu, Xiaocheng Shen, Yongjia Sun, Zhihua Molecules Article Chlorination with equimolar POCl(3) can be efficiently achieved not only for hydroxypyrimidines, but also for many other substrates such as 2-hydroxy-pyridines, -quinoxalines, or even -amides. The procedure is solvent-free and involves heating in a sealed reactor at high temperatures using one equivalent of pyridine as base. It is suitable for large scale (multigram) batch preparations. MDPI 2012-04-16 /pmc/articles/PMC6290571/ /pubmed/22508333 http://dx.doi.org/10.3390/molecules17044533 Text en © 2012 by the authors; http://creativecommons.org/licenses/by/3.0/ licensee MDPI, Basel, Switzerland. This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Wang, Han
Wen, Kun
Wang, Le
Xiang, Ye
Xu, Xiaocheng
Shen, Yongjia
Sun, Zhihua
Large-Scale Solvent-Free Chlorination of Hydroxy-Pyrimidines, -Pyridines, -Pyrazines and -Amides Using Equimolar POCl(3)
title Large-Scale Solvent-Free Chlorination of Hydroxy-Pyrimidines, -Pyridines, -Pyrazines and -Amides Using Equimolar POCl(3)
title_full Large-Scale Solvent-Free Chlorination of Hydroxy-Pyrimidines, -Pyridines, -Pyrazines and -Amides Using Equimolar POCl(3)
title_fullStr Large-Scale Solvent-Free Chlorination of Hydroxy-Pyrimidines, -Pyridines, -Pyrazines and -Amides Using Equimolar POCl(3)
title_full_unstemmed Large-Scale Solvent-Free Chlorination of Hydroxy-Pyrimidines, -Pyridines, -Pyrazines and -Amides Using Equimolar POCl(3)
title_short Large-Scale Solvent-Free Chlorination of Hydroxy-Pyrimidines, -Pyridines, -Pyrazines and -Amides Using Equimolar POCl(3)
title_sort large-scale solvent-free chlorination of hydroxy-pyrimidines, -pyridines, -pyrazines and -amides using equimolar pocl(3)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290571/
https://www.ncbi.nlm.nih.gov/pubmed/22508333
http://dx.doi.org/10.3390/molecules17044533
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