Precise Dissolution Control and Bioavailability Evaluation for Insoluble Drug Berberine via a Polymeric Particle Prepared Using Supercritical CO(2)

It is still controversial whether poor aqueous solubility is the most primary reason for the low oral bioavailability of insoluble drugs. Therefore, in this study, berberine-loaded solid polymeric particles (BPs) of varied dissolution profiles with β-cyclodextrin (β-CD) as carrier were fabricated us...

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Detalles Bibliográficos
Autores principales: Jia, Jingfu, Zhang, Kerong, Zhou, Xue, Zhou, Dan, Ge, Fahuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290634/
https://www.ncbi.nlm.nih.gov/pubmed/30961123
http://dx.doi.org/10.3390/polym10111198

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290634/
https://www.ncbi.nlm.nih.gov/pubmed/30961123
http://dx.doi.org/10.3390/polym10111198

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