Major changes of cell function and toxicant sensitivity in cultured cells undergoing mild, quasi-natural genetic drift

Genomic drift affects the functional properties of cell lines, and the reproducibility of data from in vitro studies. While chromosomal aberrations and mutations in single pivotal genes are well explored, little is known about effects of minor, possibly pleiotropic, genome changes. We addressed this...

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Detalles Bibliográficos
Autores principales: Gutbier, Simon, May, Patrick, Berthelot, Sylvie, Krishna, Abhimanyu, Trefzer, Timo, Behbehani, Mehri, Efremova, Liudmila, Delp, Johannes, Gstraunthaler, Gerhard, Waldmann, Tanja, Leist, Marcel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2018
Materias:
In Vitro Systems
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290691/
https://www.ncbi.nlm.nih.gov/pubmed/30298209
http://dx.doi.org/10.1007/s00204-018-2326-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290691/
https://www.ncbi.nlm.nih.gov/pubmed/30298209
http://dx.doi.org/10.1007/s00204-018-2326-5

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