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Major changes of cell function and toxicant sensitivity in cultured cells undergoing mild, quasi-natural genetic drift
Genomic drift affects the functional properties of cell lines, and the reproducibility of data from in vitro studies. While chromosomal aberrations and mutations in single pivotal genes are well explored, little is known about effects of minor, possibly pleiotropic, genome changes. We addressed this...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer Berlin Heidelberg
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290691/ https://www.ncbi.nlm.nih.gov/pubmed/30298209 http://dx.doi.org/10.1007/s00204-018-2326-5 |