Disruption of beta cell acetyl-CoA carboxylase-1 in mice impairs insulin secretion and beta cell mass

AIMS/HYPOTHESIS: Pancreatic beta cells secrete insulin to maintain glucose homeostasis, and beta cell failure is a hallmark of type 2 diabetes. Glucose triggers insulin secretion in beta cells via oxidative mitochondrial pathways. However, it also feeds mitochondrial anaplerotic pathways, driving ci...

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Detalles Bibliográficos
Autores principales: Cantley, James, Davenport, Aimee, Vetterli, Laurène, Nemes, Nandor J., Whitworth, P. Tess, Boslem, Ebru, Thai, Le May, Mellett, Natalie, Meikle, Peter J., Hoehn, Kyle L., James, David E., Biden, Trevor J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290731/
https://www.ncbi.nlm.nih.gov/pubmed/30334081
http://dx.doi.org/10.1007/s00125-018-4743-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290731/
https://www.ncbi.nlm.nih.gov/pubmed/30334081
http://dx.doi.org/10.1007/s00125-018-4743-7

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