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Reversible senescence of human colon cancer cells after blockage of mitosis/cytokinesis caused by the CNF1 cyclomodulin from Escherichia coli

Cytotoxic necrotizing factor 1 (CNF1), a protein toxin produced by extraintestinal pathogenic Escherichia coli, activates the Rho-family small GTPases in eukaryotic cell, thereby perturbing multiple cellular functions. Increasing epidemiological evidence suggests a link between CNF1 and human inflam...

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Detalles Bibliográficos
Autores principales: Zhang, Zhen, Aung, Kyaw Min, Uhlin, Bernt Eric, Wai, Sun Nyunt
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290797/
https://www.ncbi.nlm.nih.gov/pubmed/30542142
http://dx.doi.org/10.1038/s41598-018-36036-5