The transcription factor STAT6 plays a critical role in promoting beta cell viability and is depleted in islets of individuals with type 1 diabetes

AIMS/HYPOTHESIS: In type 1 diabetes, selective beta cell loss occurs within the inflamed milieu of insulitic islets. This milieu is generated via the enhanced secretion of proinflammatory cytokines and by the loss of anti-inflammatory molecules such as IL-4 and IL-13. While the actions of proinflamm...

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Detalles Bibliográficos
Autores principales: Leslie, Kaiyven A., Russell, Mark A., Taniguchi, Kazuto, Richardson, Sarah J., Morgan, Noel G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290857/
https://www.ncbi.nlm.nih.gov/pubmed/30338340
http://dx.doi.org/10.1007/s00125-018-4750-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290857/
https://www.ncbi.nlm.nih.gov/pubmed/30338340
http://dx.doi.org/10.1007/s00125-018-4750-8

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