ORY-1001 Suppresses Cell Growth and Induces Apoptosis in Lung Cancer Through Triggering HK2 Mediated Warburg Effect

ORY-1001, an inhibitor of covalent lysine (K)-specific demethylase 1A (KDM1A), has been used as a therapy for the treatment of acute leukemia. However, the underlying mechanisms of anticancer are still not fully elucidated. Here, we report that KDM1A is highly expressed in lung cancers, where it app...

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Detalles Bibliográficos
Autores principales: Lu, Zhaoliang, Guo, Yanke, Zhang, Xiaoya, Li, Jing, Li, Leilei, Zhang, Shuai, Shan, Changliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290890/
https://www.ncbi.nlm.nih.gov/pubmed/30568590
http://dx.doi.org/10.3389/fphar.2018.01411

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290890/
https://www.ncbi.nlm.nih.gov/pubmed/30568590
http://dx.doi.org/10.3389/fphar.2018.01411

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