Tideglusib Rescues Neurite Pathology of SPG11 iPSC Derived Cortical Neurons

Mutations in SPG11 cause a complicated autosomal recessive form of hereditary spastic paraplegia (HSP). Mechanistically, there are indications for the dysregulation of the GSK3β/βCat signaling pathway in SPG11. In this study, we tested the therapeutic potential of the GSK3β inhibitor, tideglusib, to...

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Detalles Bibliográficos
Autores principales: Pozner, Tatyana, Schray, Annika, Regensburger, Martin, Lie, Dieter Chichung, Schlötzer-Schrehardt, Ursula, Winkler, Jürgen, Turan, Soeren, Winner, Beate
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291617/
https://www.ncbi.nlm.nih.gov/pubmed/30574063
http://dx.doi.org/10.3389/fnins.2018.00914

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291617/
https://www.ncbi.nlm.nih.gov/pubmed/30574063
http://dx.doi.org/10.3389/fnins.2018.00914

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