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Tideglusib Rescues Neurite Pathology of SPG11 iPSC Derived Cortical Neurons
Mutations in SPG11 cause a complicated autosomal recessive form of hereditary spastic paraplegia (HSP). Mechanistically, there are indications for the dysregulation of the GSK3β/βCat signaling pathway in SPG11. In this study, we tested the therapeutic potential of the GSK3β inhibitor, tideglusib, to...
Autores principales: | Pozner, Tatyana, Schray, Annika, Regensburger, Martin, Lie, Dieter Chichung, Schlötzer-Schrehardt, Ursula, Winkler, Jürgen, Turan, Soeren, Winner, Beate |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291617/ https://www.ncbi.nlm.nih.gov/pubmed/30574063 http://dx.doi.org/10.3389/fnins.2018.00914 |
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