TLR3 agonism re‐establishes CNS immune competence during α4‐integrin deficiency

OBJECTIVE: Natalizumab blocks α4‐integrin‐mediated leukocyte migration into the central nervous system (CNS). It diminishes disease activity in multiple sclerosis (MS), but carries a high risk of progressive multifocal encephalopathy (PML), an opportunistic infection with JV virus that may be prompt...

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Detalles Bibliográficos
Autores principales: Hussain, Rehana Z., Cravens, Petra C., Doelger, Richard, Dentel, Brianne, Herndon, Emily, Loof, Nicolas, Tsai, Peter, Okuda, Darin T., Racke, Michael K., Stüve, Olaf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292184/
https://www.ncbi.nlm.nih.gov/pubmed/30564621
http://dx.doi.org/10.1002/acn3.664

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292184/
https://www.ncbi.nlm.nih.gov/pubmed/30564621
http://dx.doi.org/10.1002/acn3.664

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