Protein production is an early biomarker for RNA‐targeted therapies

OBJECTIVES: Clinical trials for progressive neurodegenerative disorders such as Alzheimer's Disease and Amyotrophic Lateral Sclerosis have been hindered due to the absence of effective pharmacodynamics markers to assay target engagement. We tested whether measurements of new protein production...

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Detalles Bibliográficos
Autores principales: Self, Wade K., Schoch, Kathleen M., Alex, Jacob, Barthélemy, Nicolas, Bollinger, James G., Sato, Chihiro, Cole, Tracy, Kordasiewicz, Holly B., Swayze, Eric, Bateman, Randall J., Miller, Timothy M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292185/
https://www.ncbi.nlm.nih.gov/pubmed/30564616
http://dx.doi.org/10.1002/acn3.657

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292185/
https://www.ncbi.nlm.nih.gov/pubmed/30564616
http://dx.doi.org/10.1002/acn3.657

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