Pilot trial of inosine to elevate urate levels in amyotrophic lateral sclerosis

OBJECTIVE: To test the safety, tolerability, and urate‐elevating capability of the urate precursor inosine taken orally or by feeding tube in people with amyotrophic lateral sclerosis (ALS). METHODS: This was a pilot, open‐label trial in 25 participants with ALS. Treatment duration was 12 weeks. The...

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Detalles Bibliográficos
Autores principales: Nicholson, Katharine, Chan, James, Macklin, Eric A., Levine‐Weinberg, Mark, Breen, Christopher, Bakshi, Rachit, Grasso, Daniela L., Wills, Anne‐Marie, Jahandideh, Samad, Taylor, Albert A., Beaulieu, Danielle, Ennist, David L., Andronesi, Ovidiu, Ratai, Eva‐Maria, Schwarzschild, Michael A., Cudkowicz, Merit, Paganoni, Sabrina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292193/
https://www.ncbi.nlm.nih.gov/pubmed/30564619
http://dx.doi.org/10.1002/acn3.671

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