Ribonuclease H1-targeted R-loops in surface antigen gene expression sites can direct trypanosome immune evasion

Switching of the Variant Surface Glycoprotein (VSG) in Trypanosoma brucei provides a crucial host immune evasion strategy that is catalysed both by transcription and recombination reactions, each operating within specialised telomeric VSG expression sites (ES). VSG switching is likely triggered by e...

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Detalles Bibliográficos
Autores principales: Briggs, Emma, Crouch, Kathryn, Lemgruber, Leandro, Lapsley, Craig, McCulloch, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292569/
https://www.ncbi.nlm.nih.gov/pubmed/30543624
http://dx.doi.org/10.1371/journal.pgen.1007729

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292569/
https://www.ncbi.nlm.nih.gov/pubmed/30543624
http://dx.doi.org/10.1371/journal.pgen.1007729

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