Cargando…
A unique subset of low-risk Wilms tumors is characterized by loss of function of TRIM28 (KAP1), a gene critical in early renal development: A Children’s Oncology Group study
This study explores the genomic alterations that contribute to the formation of a unique subset of low-risk, epithelial differentiated, favorable histology Wilms tumors (WT), tumors that have been characterized by their expression of post-induction renal developmental genes (Subset 1 WT). We demonst...
Autores principales: | Armstrong, Amy E., Gadd, Samantha, Huff, Vicki, Gerhard, Daniela S., Dome, Jeffrey S., Perlman, Elizabeth J. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292605/ https://www.ncbi.nlm.nih.gov/pubmed/30543698 http://dx.doi.org/10.1371/journal.pone.0208936 |
Ejemplares similares
-
TRIM28 variants and Wilms' tumour predisposition
por: Hol, Janna A, et al.
Publicado: (2021) -
A Children's Oncology Group and TARGET Initiative Exploring the Genetic Landscape of Wilms Tumor
por: Gadd, Samantha, et al.
Publicado: (2017) -
Germline mutations and somatic inactivation of TRIM28 in Wilms tumour
por: Halliday, Benjamin J., et al.
Publicado: (2018) -
Infertility-Causing Haploinsufficiency Reveals TRIM28/KAP1 Requirement in Spermatogonia
por: Tan, Joel H.L., et al.
Publicado: (2020) -
KAP1/TRIM28: Transcriptional Activator and/or Repressor of Viral and Cellular Programs?
por: Randolph, Keyera, et al.
Publicado: (2022)