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Amino acid residues in five separate HLA genes can explain most of the known associations between the MHC and primary biliary cholangitis
Primary Biliary Cholangitis (PBC) is a chronic autoimmune liver disease characterised by progressive destruction of intrahepatic bile ducts. The strongest genetic association is with HLA-DQA1*04:01, but at least three additional independent HLA haplotypes contribute to susceptibility. We used dense...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292650/ https://www.ncbi.nlm.nih.gov/pubmed/30507971 http://dx.doi.org/10.1371/journal.pgen.1007833 |