Amino acid residues in five separate HLA genes can explain most of the known associations between the MHC and primary biliary cholangitis

Primary Biliary Cholangitis (PBC) is a chronic autoimmune liver disease characterised by progressive destruction of intrahepatic bile ducts. The strongest genetic association is with HLA-DQA1*04:01, but at least three additional independent HLA haplotypes contribute to susceptibility. We used dense...

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Detalles Bibliográficos
Autores principales: Darlay, Rebecca, Ayers, Kristin L., Mells, George F., Hall, Lynsey S., Liu, Jimmy Z., Almarri, Mohamed A., Alexander, Graeme J., Jones, David E., Sandford, Richard N., Anderson, Carl A., Cordell, Heather J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292650/
https://www.ncbi.nlm.nih.gov/pubmed/30507971
http://dx.doi.org/10.1371/journal.pgen.1007833

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292650/
https://www.ncbi.nlm.nih.gov/pubmed/30507971
http://dx.doi.org/10.1371/journal.pgen.1007833

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