Key role of the REC lobe during CRISPR–Cas9 activation by ‘sensing’, ‘regulating’, and ‘locking’ the catalytic HNH domain

Understanding the conformational dynamics of CRISPR (clustered regularly interspaced short palindromic repeat)–Cas9 is of the utmost importance for improving its genome editing capability. Here, molecular dynamics simulations performed using Anton-2 – a specialized supercomputer capturing micro-to-m...

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Detalles Bibliográficos
Autores principales: Palermo, Giulia, Chen, Janice S., Ricci, Clarisse G., Rivalta, Ivan, Jinek, Martin, Batista, Victor S., Doudna, Jennifer A., McCammon, J. Andrew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292676/
https://www.ncbi.nlm.nih.gov/pubmed/30555184
http://dx.doi.org/10.1017/S0033583518000070

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292676/
https://www.ncbi.nlm.nih.gov/pubmed/30555184
http://dx.doi.org/10.1017/S0033583518000070

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