The sterol-responsive RNF145 E3 ubiquitin ligase mediates the degradation of HMG-CoA reductase together with gp78 and Hrd1

Mammalian HMG-CoA reductase (HMGCR), the rate-limiting enzyme of the cholesterol biosynthetic pathway and the therapeutic target of statins, is post-transcriptionally regulated by sterol-accelerated degradation. Under cholesterol-replete conditions, HMGCR is ubiquitinated and degraded, but the ident...

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Detalles Bibliográficos
Autores principales: Menzies, Sam A, Volkmar, Norbert, van den Boomen, Dick JH, Timms, Richard T, Dickson, Anna S, Nathan, James A, Lehner, Paul J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292692/
https://www.ncbi.nlm.nih.gov/pubmed/30543180
http://dx.doi.org/10.7554/eLife.40009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292692/
https://www.ncbi.nlm.nih.gov/pubmed/30543180
http://dx.doi.org/10.7554/eLife.40009

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