The transcription factors TFE3 and TFEB amplify p53 dependent transcriptional programs in response to DNA damage

The transcription factors TFE3 and TFEB cooperate to regulate autophagy induction and lysosome biogenesis in response to starvation. Here we demonstrate that DNA damage activates TFE3 and TFEB in a p53 and mTORC1 dependent manner. RNA-Seq analysis of TFEB/TFE3 double-knockout cells exposed to etopos...

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Detalles Bibliográficos
Autores principales: Brady, Owen A, Jeong, Eutteum, Martina, José A, Pirooznia, Mehdi, Tunc, Ilker, Puertollano, Rosa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292694/
https://www.ncbi.nlm.nih.gov/pubmed/30520728
http://dx.doi.org/10.7554/eLife.40856

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292694/
https://www.ncbi.nlm.nih.gov/pubmed/30520728
http://dx.doi.org/10.7554/eLife.40856

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