Crystal structure and mutation analysis revealed that DREP2 CIDE forms a filament-like structure with features differing from those of DREP4 CIDE

Cell death-inducing DFF45-like effect (CIDE) domain-containing proteins, DFF40, DFF45, CIDE-A, CIDE-B, and FSP27, play important roles in apoptotic DNA fragmentation and lipid homeostasis. The function of DFF40/45 in apoptotic DNA fragmentation is mediated by CIDE domain filament formation. Although...

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Detalles Bibliográficos
Autores principales: Ha, Hyun Ji, Park, Hyun Ho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292858/
https://www.ncbi.nlm.nih.gov/pubmed/30546036
http://dx.doi.org/10.1038/s41598-018-36253-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292858/
https://www.ncbi.nlm.nih.gov/pubmed/30546036
http://dx.doi.org/10.1038/s41598-018-36253-y

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