Cargando…

Characterisation of small molecule ligands 4CMTB and 2CTAP as modulators of human FFA2 receptor signalling

Short chain fatty acids (SCFAs) are protective against inflammatory diseases. Free fatty acid receptor 2 (FFA2), is a target of SCFAs however, their selectivity for FFA2 over other FFA receptors is limited. This study aimed to functionally characterise 2-(4-chlorophenyl)-3-methyl-N-(thiazole-2-yl)bu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Schofield, Zoe V., Croker, Daniel, Robertson, Avril A. B., Massey, Nicholas L., Donovan, Chantal, Tee, Ernest, Edwards, David, Woodruff, Trent M., Halai, Reena, Hansbro, Philip M., Cooper, Matthew A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292860/ https://www.ncbi.nlm.nih.gov/pubmed/30546040 http://dx.doi.org/10.1038/s41598-018-36242-1

Ejemplares similares

4-CMTB Ameliorates Ovalbumin-Induced Allergic Asthma through FFA2 Activation in Mice
por: Lee, Ju-Hyun, et al.
Publicado: (2021)

Role of platelet chemokines, PF-4 and CTAP-III, in cancer biology
por: Pilatova, Katerina, et al.
Publicado: (2013)

Selective Orthosteric Free Fatty Acid Receptor 2 (FFA2) Agonists: IDENTIFICATION OF THE STRUCTURAL AND CHEMICAL REQUIREMENTS FOR SELECTIVE ACTIVATION OF FFA2 VERSUS FFA3
por: Schmidt, Johannes, et al.
Publicado: (2011)

Bangladesh Chars Tobacco Assessment Project (CTAP) 2018: a data note
por: Fakir, Adnan M. S., et al.
Publicado: (2018)

OR23-4 Intestinal FFA2 and FFA3 Mediate Obesogenic Effects in Mice on a Western Diet
por: Gough, Sophie, et al.
Publicado: (2022)

Label-free cell phenotypic study of FFA4 and FFA1 and discovery of novel agonists of FFA4 from natural products
por: Xu, Fangfang, et al.
Publicado: (2019)

Pharmacological properties of acid N-thiazolylamide FFA2 agonists
por: Brown, Andrew J, et al.
Publicado: (2015)

FFA2 Contribution to Gestational Glucose Tolerance Is Not Disrupted by Antibiotics
por: Fuller, Miles, et al.
Publicado: (2016)

Short-chain free fatty acid receptors FFA2/GPR43 and FFA3/GPR41 as new potential therapeutic targets
por: Ulven, Trond
Publicado: (2012)

Long Chain Fatty Acids as Modulators of Immune Cells Function: Contribution of FFA1 and FFA4 Receptors
por: Hidalgo, Maria A., et al.
Publicado: (2021)

FFA2-, but not FFA3-agonists inhibit GSIS of human pseudoislets: a comparative study with mouse islets and rat INS-1E cells
por: Lorza-Gil, Estela, et al.
Publicado: (2020)

Two Permeases Associated with the Multifunctional CtaP Cysteine Transport System in Listeria monocytogenes Play Distinct Roles in Pathogenesis
por: Vaval Taylor, Diandra M., et al.
Publicado: (2023)

Extracellular Ionic Locks Determine Variation in Constitutive Activity and Ligand Potency between Species Orthologs of the Free Fatty Acid Receptors FFA2 and FFA3
por: Hudson, Brian D., et al.
Publicado: (2012)

Derivation of ligands for the complement C3a receptor from the C-terminus of C5a
por: Halai, Reena, et al.
Publicado: (2014)

Study of the Binding Pattern of HLA Class I Alleles of Indian Frequency and cTAP Binding Peptide for Chikungunya Vaccine Development
por: Saxena, Prashant, et al.
Publicado: (2020)

Predicting the targets of IRF8 and NFATc1 during osteoclast differentiation using the machine learning method framework cTAP
por: Wang, Honglin, et al.
Publicado: (2022)

FFA2 Activation Ameliorates 2,4-Dinitrochlorobenzene-Induced Atopic Dermatitis in Mice
por: Kang, Jisoo, et al.
Publicado: (2020)

Chikungunya Virus Vaccine Development: Through Computational Proteome Exploration for Finding of HLA and cTAP Binding Novel Epitopes as Vaccine Candidates
por: Sharma, Priti, et al.
Publicado: (2022)

Control of Fibrinogen Biosynthesis: Role of the FFA/Albumin Ratio
por: Pilgeram, Laurence
Publicado: (2010)

FFA4/GPR120: Pharmacology and Therapeutic Opportunities
por: Milligan, Graeme, et al.
Publicado: (2017)

The Specificity and Broad Multitarget Properties of Ligands for the Free Fatty Acid Receptors FFA3/GPR41 and FFA2/GPR43 and the Related Hydroxycarboxylic Acid Receptor HCA2/GPR109A
por: Bisenieks, Egils, et al.
Publicado: (2021)

A Comparative Study of Impedance versus Optical Label-Free Systems Relative to Labelled Assays in a Predominantly Gi Coupled GPCR (C5aR) Signalling
por: Halai, Reena, et al.
Publicado: (2012)

Distinct response properties between the FFA to faces and the PPA to houses
por: Li, Mengjin, et al.
Publicado: (2022)

Allosteric targeting of the FFA2 receptor (GPR43) restores responsiveness of desensitized human neutrophils
por: Frei, Robert, et al.
Publicado: (2020)

FRI012 Exploring The Role Of FFA2 In Western Diet-induced Obesity And Metabolic Changes
por: Nnyamah, Christine, et al.
Publicado: (2023)

TCF2 Attenuates FFA-Induced Damage in Islet β-Cells by Regulating Production of Insulin and ROS
por: Quan, Xiaojuan, et al.
Publicado: (2014)

PSUN82 The Gut Microbiome Regulates Healthy Adipose Tissue Expansion via the Action of FFA2
por: Nnyamah, Christine, et al.
Publicado: (2022)

Modeling and implementation of vertical excursion FFA in the Zgoubi ray-tracing code
por: Vanwelde, Marion, et al.
Publicado: (2023)

Recommended protocol for performing oral fundus fluorescein angiography (FFA) in children
por: Marmoy, Oliver R., et al.
Publicado: (2020)

IPMK modulates FFA-induced insulin resistance in primary mouse hepatocytes
por: Jung, Ik-Rak, et al.
Publicado: (2023)

Defining the Molecular Basis for the First Potent and Selective Orthosteric Agonists of the FFA2 Free Fatty Acid Receptor
por: Hudson, Brian D., et al.
Publicado: (2013)

Safety, pharmacokinetics and pharmacodynamics of GLPG0974, a potent and selective FFA2 antagonist, in healthy male subjects
por: Namour, Florence, et al.
Publicado: (2016)

The SGLT2 inhibitor dapagliflozin promotes systemic FFA mobilization, enhances hepatic β-oxidation, and induces ketosis
por: Wallenius, Kristina, et al.
Publicado: (2022)

The Effect and Mechanism of TLR9/KLF4 in FFA-Induced Adipocyte Inflammation
por: Wang, Cuizhe, et al.
Publicado: (2018)

Chemical synthesis and characterisation of the complement C5 inhibitory peptide zilucoplan
por: Gorman, Declan M., et al.
Publicado: (2021)

Corrigendum: Taheebo Polyphenols Attenuate FFA-Induced Inflammation in Murine and Human Macrophage Cell Lines As Inhibitor of COX-2
por: Ma, Sihui, et al.
Publicado: (2018)

SAT073 β Cell FFA2 Deficiency Suppresses Multiple Low Dose Streptozotocin (MLDS) Induced Diabetes
por: Xu, Kai, et al.
Publicado: (2023)

Evidence for a Replication Function of Ffa-1, the Xenopus Orthologue of Werner Syndrome Protein
por: Chen, Chin-Yi, et al.
Publicado: (2001)

Consistency of the Disposition Index in the Face of Diet Induced Insulin Resistance: Potential Role of FFA
por: Stefanovski, Darko, et al.
Publicado: (2011)

The Internal Anticipation of Sensory Action Effects: When Action Induces FFA and PPA Activity
por: Kühn, Simone, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_kf9d8mi356mm17oqafctielpla