Cargando…

A yellow fever–Zika chimeric virus vaccine candidate protects against Zika infection and congenital malformations in mice

The recent Zika virus (ZIKV) epidemic in the Americas led to an intense search for therapeutics and vaccines. Here we report the engineering of a chimeric virus vaccine candidate (YF-ZIKprM/E) by replacing the antigenic surface glycoproteins and the capsid anchor of YFV-17D with those of a prototypi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kum, Dieudonné B., Mishra, Niraj, Boudewijns, Robbert, Gladwyn-Ng, Ivan, Alfano, Christian, Ma, Ji, Schmid, Michael A., Marques, Rafael E., Schols, Dominique, Kaptein, Suzanne, Nguyen, Laurent, Neyts, Johan, Dallmeier, Kai
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292895/ https://www.ncbi.nlm.nih.gov/pubmed/30564463 http://dx.doi.org/10.1038/s41541-018-0092-2

Ejemplares similares

A chimeric yellow fever-Zika virus vaccine candidate fully protects against yellow fever virus infection in mice
por: Kum, Dieudonné Buh, et al.
Publicado: (2020)

A Chimeric Japanese Encephalitis Vaccine Protects against Lethal Yellow Fever Virus Infection without Inducing Neutralizing Antibodies
por: Mishra, Niraj, et al.
Publicado: (2020)

Comparing immunogenicity and protective efficacy of the yellow fever 17D vaccine in mice
por: Ma, Ji, et al.
Publicado: (2021)

Zika Virus Replicons for Drug Discovery
por: Xie, Xuping, et al.
Publicado: (2016)

Zika and Other Emerging Viruses: Aiming at the Right Target
por: Dallmeier, Kai, et al.
Publicado: (2016)

A novel therapeutic HBV vaccine candidate induces strong polyfunctional cytotoxic T cell responses in mice
por: Boudewijns, Robbert, et al.
Publicado: (2021)

Chimeric yellow fever 17D-Zika virus (ChimeriVax-Zika) as a live-attenuated Zika virus vaccine
por: Giel-Moloney, Maryann, et al.
Publicado: (2018)

Limited evolution of the yellow fever virus 17d in a mouse infection model
por: Kum, Dieudonné Buh, et al.
Publicado: (2019)

The Viral Polymerase Inhibitor 7-Deaza-2’-C-Methyladenosine Is a Potent Inhibitor of In Vitro Zika Virus Replication and Delays Disease Progression in a Robust Mouse Infection Model
por: Zmurko, Joanna, et al.
Publicado: (2016)

Live Zika virus chimeric vaccine candidate based on a yellow fever 17-D attenuated backbone
por: Touret, Franck, et al.
Publicado: (2018)

The Unfolded Protein Response: A Key Player in Zika Virus-Associated Congenital Microcephaly
por: Alfano, Christian, et al.
Publicado: (2019)

A Viral Polymerase Inhibitor Reduces Zika Virus Replication in the Reproductive Organs of Male Mice
por: Jacobs, Sofie, et al.
Publicado: (2019)

Single dose of chimeric dengue-2/Zika vaccine candidate protects mice and non-human primates against Zika virus
por: Baldwin, Whitney R., et al.
Publicado: (2021)

A single-dose live attenuated chimeric vaccine candidate against Zika virus
por: Chin, Wei-Xin, et al.
Publicado: (2021)

Small-molecule inhibitors of TBK1 serve as an adjuvant for a plasmid-launched live-attenuated yellow fever vaccine
por: Sharma, Sapna, et al.
Publicado: (2020)

The Chimeric Binjari-Zika Vaccine Provides Long-Term Protection against ZIKA Virus Challenge
por: Hazlewood, Jessamine E., et al.
Publicado: (2022)

The legacy of ZikaPLAN: a transnational research consortium addressing Zika
por: Wilder-Smith, Annelies, et al.
Publicado: (2022)

Editorial brain malformation surveillance in the Zika era
por: Trevathan, Edwin
Publicado: (2016)

Human stem cell-derived hepatocyte-like cells support Zika virus replication and provide a relevant model to assess the efficacy of potential antivirals
por: Tricot, Tine, et al.
Publicado: (2018)

ZikaPLAN: Zika Preparedness Latin American Network
por: Wilder-Smith, A., et al.
Publicado: (2017)

Identification of host factors binding to dengue and Zika virus subgenomic RNA by efficient yeast three-hybrid screens of the human ORFeome
por: Jansen, Sander, et al.
Publicado: (2021)

A High-Throughput Yellow Fever Neutralization Assay
por: Rasulova, Madina, et al.
Publicado: (2022)

Comparing infectivity and virulence of emerging SARS-CoV-2 variants in Syrian hamsters
por: Abdelnabi, Rana, et al.
Publicado: (2021)

Virus Like Particles (VLP) as multivalent vaccine candidate against Chikungunya, Japanese Encephalitis, Yellow Fever and Zika Virus
por: Garg, Himanshu, et al.
Publicado: (2020)

Yellow fever vaccine protects mice against Zika virus infection
por: Vicente Santos, Ana C., et al.
Publicado: (2021)

Design, Synthesis and Discovery of N,N’‐Carbazoyl‐aryl‐urea Inhibitors of Zika NS5 Methyltransferase and Virus Replication
por: Spizzichino, Sharon, et al.
Publicado: (2020)

A SCID Mouse Model To Evaluate the Efficacy of Antivirals against SARS-CoV-2 Infection
por: Abdelnabi, Rana, et al.
Publicado: (2022)

Dengue, Yellow Fever, Zika and Chikungunya epidemic arboviruses in Brazil: ultrastructural aspects
por: Barreto-Vieira, Debora Ferreira, et al.
Publicado: (2021)

Zika genomics urgently need standardized and curated reference sequences
por: Theys, Kristof, et al.
Publicado: (2017)

Zika virus differentially infects human neural progenitor cells according to their state of differentiation and dysregulates neurogenesis through the Notch pathway
por: Ferraris, Pauline, et al.
Publicado: (2019)

Zika Virus: A New Therapeutic Candidate for Glioblastoma Treatment
por: Francipane, Maria Giovanna, et al.
Publicado: (2021)

Understanding Zika Virus Stability and Developing a Chimeric Vaccine through Functional Analysis
por: Xie, Xuping, et al.
Publicado: (2017)

Zika Virus
por: Masmejan, Sophie, et al.
Publicado: (2020)

Asymptomatic Prenatal Zika Virus Infection and Congenital Zika Syndrome
por: Paixao, Enny S, et al.
Publicado: (2018)

Zika Virus Speed and Direction: Reconstructing Zika Introduction in Brazil
por: Zinszer, Kate, et al.
Publicado: (2017)

Human Schwann cells are susceptible to infection with Zika and yellow fever viruses, but not dengue virus
por: Dhiman, Gaurav, et al.
Publicado: (2019)

Epidemiology and Laboratory Diagnostics of Dengue, Yellow Fever, Zika, and Chikungunya Virus Infections in Africa
por: Adam, Awadalkareem, et al.
Publicado: (2021)

Comparative Infections of Zika, Dengue, and Yellow Fever Viruses in Human Cytotrophoblast-Derived Cells Suggest a Gating Role for the Cytotrophoblast in Zika Virus Placental Invasion
por: Viettri, Mercedes, et al.
Publicado: (2023)

The cyanobacterial saxitoxin exacerbates neural cell death and brain malformations induced by Zika virus
por: Pedrosa, Carolina da S. G., et al.
Publicado: (2020)

Exploring the immunogenicity of an insect-specific virus vectored Zika vaccine candidate
por: Tanelus, Manette, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_3jb071org81nc537ak6vdfj4s8