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The formation of chromatin domains involves a primary step based on the 3-D structure of DNA
The general model presented here for the formation of chromatin domains, LADs and TADs, is primarily based on the 3-D structures of the corresponding DNA sequences, the GC-poor and GC-rich isochores. Indeed, the low-heterogeneity GC-poor isochores locally are intrinsically stiff and curved because o...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2018
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292937/ https://www.ncbi.nlm.nih.gov/pubmed/30546050 http://dx.doi.org/10.1038/s41598-018-35851-0 |