Variants of DNMT3A cause transcript-specific DNA methylation patterns and affect hematopoiesis

De novo DNA methyltransferase 3A (DNMT3A) plays pivotal roles in hematopoietic differentiation. In this study, we followed the hypothesis that alternative splicing of DNMT3A has characteristic epigenetic and functional sequels. Specific DNMT3A transcripts were either down-regulated or overexpressed...

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Detalles Bibliográficos
Autores principales: Božić, Tanja, Frobel, Joana, Raic, Annamarija, Ticconi, Fabio, Kuo, Chao-Chung, Heilmann-Heimbach, Stefanie, Goecke, Tamme W, Zenke, Martin, Jost, Edgar, Costa, Ivan G, Wagner, Wolfgang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293073/
https://www.ncbi.nlm.nih.gov/pubmed/30582132
http://dx.doi.org/10.26508/lsa.201800153

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293073/
https://www.ncbi.nlm.nih.gov/pubmed/30582132
http://dx.doi.org/10.26508/lsa.201800153

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