Novel features in the structure of P-glycoprotein (ABCB1) in the post-hydrolytic state as determined at 7.9 Å resolution

BACKGROUND: P-glycoprotein (ABCB1) is an ATP-binding cassette transporter that plays an important role in the clearance of drugs and xenobiotics and is associated with multi-drug resistance in cancer. Although several P-glycoprotein structures are available, these are either at low resolution, or re...

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Detalles Bibliográficos
Autores principales: Thonghin, Nopnithi, Collins, Richard F., Barbieri, Alessandro, Shafi, Talha, Siebert, Alistair, Ford, Robert C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293506/
https://www.ncbi.nlm.nih.gov/pubmed/30545335
http://dx.doi.org/10.1186/s12900-018-0098-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293506/
https://www.ncbi.nlm.nih.gov/pubmed/30545335
http://dx.doi.org/10.1186/s12900-018-0098-z

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