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ErbB2-driven downregulation of the transcription factor Irf6 in breast epithelial cells is required for their 3D growth
BACKGROUND: The ability of solid tumor cells to resist anoikis, apoptosis triggered by cell detachment from the extracellular matrix (ECM), is thought to be critical for 3D tumor growth. ErbB2/Her2 oncoprotein is often overproduced by breast tumor cells and blocks their anoikis by partially understo...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293553/ https://www.ncbi.nlm.nih.gov/pubmed/30545388 http://dx.doi.org/10.1186/s13058-018-1080-1 |