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Metformin regulates atrial SK2 and SK3 expression through inhibiting the PKC/ERK signaling pathway in type 2 diabetic rats

BACKGROUND: Our previous study showed that metformin regulates the mRNA and protein levels of type 2 small conductance calcium-activated potassium channel (SK2) and type 3 small conductance calcium-activated potassium channels (SK3) in atrial tissue as well as the ion current of atrial myocytes in r...

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Detalles Bibliográficos
Autores principales: Liu, Chang-He, Hua, Na, Fu, Xi, Pan, Yi-Long, Li, Bin, Li, Xiao-Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293565/
https://www.ncbi.nlm.nih.gov/pubmed/30545309
http://dx.doi.org/10.1186/s12872-018-0950-x