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The PIK3CA E542K and E545K mutations promote glycolysis and proliferation via induction of the β-catenin/SIRT3 signaling pathway in cervical cancer
BACKGROUND: The study aims to present the effect of PIK3CA E542K and E545K mutations on glucose metabolism and proliferation and identify their underlying mechanisms in cervical cancer. METHODS: The maximum standard uptake value (SUV(max)) of tumors was detected by(18)F-FDG PET/CT scan. In vitro, gl...
Autores principales: | Jiang, Wei, He, Tiancong, Liu, Shuai, Zheng, Yingying, Xiang, Libing, Pei, Xuan, Wang, Ziliang, Yang, Huijuan |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293652/ https://www.ncbi.nlm.nih.gov/pubmed/30547809 http://dx.doi.org/10.1186/s13045-018-0674-5 |
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