Mind the gaps: overlooking inaccessible regions confounds statistical testing in genome analysis

BACKGROUND: The current versions of reference genome assemblies still contain gaps represented by stretches of Ns. Since high throughput sequencing reads cannot be mapped to those gap regions, the regions are depleted of experimental data. Moreover, several technology platforms assay a targeted port...

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Detalles Bibliográficos
Autores principales: Domanska, Diana, Kanduri, Chakravarthi, Simovski, Boris, Sandve, Geir Kjetil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293655/
https://www.ncbi.nlm.nih.gov/pubmed/30547739
http://dx.doi.org/10.1186/s12859-018-2438-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293655/
https://www.ncbi.nlm.nih.gov/pubmed/30547739
http://dx.doi.org/10.1186/s12859-018-2438-1

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