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Mind the gaps: overlooking inaccessible regions confounds statistical testing in genome analysis
BACKGROUND: The current versions of reference genome assemblies still contain gaps represented by stretches of Ns. Since high throughput sequencing reads cannot be mapped to those gap regions, the regions are depleted of experimental data. Moreover, several technology platforms assay a targeted port...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293655/ https://www.ncbi.nlm.nih.gov/pubmed/30547739 http://dx.doi.org/10.1186/s12859-018-2438-1 |