miR-122 removal in the liver activates imprinted microRNAs and enables more effective microRNA-mediated gene repression

miR-122 is a highly expressed liver microRNA that is activated perinatally and aids in regulating cholesterol metabolism and promoting terminal differentiation of hepatocytes. Disrupting expression of miR-122 can re-activate embryo-expressed adult-silenced genes, ultimately leading to the developmen...

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Detalles Bibliográficos
Autores principales: Valdmanis, Paul N., Kim, Hak Kyun, Chu, Kirk, Zhang, Feijie, Xu, Jianpeng, Munding, Elizabeth M., Shen, Jia, Kay, Mark A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294001/
https://www.ncbi.nlm.nih.gov/pubmed/30552326
http://dx.doi.org/10.1038/s41467-018-07786-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294001/
https://www.ncbi.nlm.nih.gov/pubmed/30552326
http://dx.doi.org/10.1038/s41467-018-07786-7

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