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miR-122 removal in the liver activates imprinted microRNAs and enables more effective microRNA-mediated gene repression
miR-122 is a highly expressed liver microRNA that is activated perinatally and aids in regulating cholesterol metabolism and promoting terminal differentiation of hepatocytes. Disrupting expression of miR-122 can re-activate embryo-expressed adult-silenced genes, ultimately leading to the developmen...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294001/ https://www.ncbi.nlm.nih.gov/pubmed/30552326 http://dx.doi.org/10.1038/s41467-018-07786-7 |