Lysosomotropic drugs activate TFEB via lysosomal membrane fluidization and consequent inhibition of mTORC1 activity

Transcription factor EB (TFEB) is a master transcriptional regulator playing a key role in lysosomal biogenesis, autophagy and lysosomal exocytosis. TFEB activity is inhibited following its phosphorylation by mammalian target of rapamycin complex 1 (mTORC1) on the surface of the lysosome. Phosphoryl...

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Detalles Bibliográficos
Autores principales: Zhitomirsky, Benny, Yunaev, Anna, Kreiserman, Roman, Kaplan, Ariel, Stark, Michal, Assaraf, Yehuda G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294013/
https://www.ncbi.nlm.nih.gov/pubmed/30546014
http://dx.doi.org/10.1038/s41419-018-1227-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294013/
https://www.ncbi.nlm.nih.gov/pubmed/30546014
http://dx.doi.org/10.1038/s41419-018-1227-0

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