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Mixing lipids to manipulate the ionization status of lipid nanoparticles for specific tissue targeting
INTRODUCTION: The development of targeted drug delivery systems is a rapidly growing area in the field of nanomedicine. METHODS: We report herein on optimizing the targeting efficiency of a lipid nanoparticle (LNP) by manipulating the acid dissociation constant (pKa) value of its membrane, which ref...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294068/ https://www.ncbi.nlm.nih.gov/pubmed/30587967 http://dx.doi.org/10.2147/IJN.S188016 |