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Mixing lipids to manipulate the ionization status of lipid nanoparticles for specific tissue targeting

INTRODUCTION: The development of targeted drug delivery systems is a rapidly growing area in the field of nanomedicine. METHODS: We report herein on optimizing the targeting efficiency of a lipid nanoparticle (LNP) by manipulating the acid dissociation constant (pKa) value of its membrane, which ref...

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Detalles Bibliográficos
Autores principales:	Shobaki, Nour, Sato, Yusuke, Harashima, Hideyoshi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2018
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294068/ https://www.ncbi.nlm.nih.gov/pubmed/30587967 http://dx.doi.org/10.2147/IJN.S188016

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